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Article

Activation of STAT3 and inhibitory effects of pioglitazone on STAT3 activity in a mouse model of SOD1-mutated amyotrophic lateral sclerosis.

Neuropathology : official journal of the Japanese Society of Neuropathology - 1 Aug 2010

Shibata Noriyuki, Yamamoto Tomoko, Hiroi Atsuko, Omi Yoko, Kato Yoichiro, Kobayashi Makio

Abstract excerpt

Signal transducer and activator of transcription-3 (STAT3) is a member of the proinflammatory transcription factor STAT family. Several studies have documented implications for neuroinflammation in amyotrophic lateral sclerosis (ALS). We recently demonstrated activation of STAT3 in spinal cords obtained at autopsy from sporadic ALS patients. To determine the involvement of STAT3 and effects of pioglitazone on...

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Source

Identifiers

PMID: 19925559
DOI: 10.1111/j.1440-1789.2009.01078.x

Genes

STAT3
SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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