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Article

Fas ligand: a sensor for DNA damage critical in skin cancer etiology.

Science (New York, N.Y.) - 6 Aug 1999

Hill L L, Ouhtit A, Loughlin S M, Kripke M L, Ananthaswamy H N, Owen-Schaub L B

Abstract excerpt

DNA-damaged cells can either repair the DNA or be eliminated through a homeostatic control mechanism termed "cellular proofreading." Elimination of DNA-damaged cells after ultraviolet radiation (UVR) through sunburn cell (apoptotic keratinocyte) formation is thought to be pivotal for the removal of precancerous skin cells. Sunburn cell formation was found to be dependent on Fas ligand (FasL), a pro-apoptotic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10436160
DOI: 10.1126/science.285.5429.898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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