Article
A host-specific function is required for ligation of a wide variety of ribozyme-processed RNAs.
Proceedings of the National Academy of Sciences of the United States of America - 4 Jan 2000
Reid C E, Lazinski D W
Abstract excerpt
Hepatitis delta virus (HDV) replicates its circular RNA genome via a rolling circle mechanism. During this process, cis-acting ribozymes cleave adjacent upstream sequences and thereby resolve replication intermediates to unit-length RNA. The subsequent ligation of these 5'OH and 2',3'-cyclic phosphate termini to form circular RNA is an essential step in the life cycle of the virus. Here we present evidence for...
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