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Article

Diversity, functionality, and stability of the T cell repertoire derived <i>in vivo</i> from a single human T cell precursor

4 Jan 2000

Abstract excerpt

In this report, we have analyzed the human T cell repertoire derived in vivo from a single T cell precursor. A unique case of X-linked severe combined immunodeficiency in which a reverse mutation occurred in an early T cell precursor was analyzed to this end. It was determined that at least 1,000 T cell clones with unique T cell receptor-beta sequences were generated from this precursor. This diversity seems to...

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PMID: 10618408
DOI: 10.1073/pnas.97.1.274

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