Article
Progress in the immunogenetics of rheumatoid arthritis.
Hospital practice (Office ed.) - 15 Apr 1995
Wordsworth P
Abstract excerpt
Although much remains to be learned about environmental factors and putative pathogens, significant strides have been made on the genetic front. Genes appear to have a greater role in determining disease severity than disease risk. In particular, patients who are heterozygous for two HLA-DR4 subtypes are prone to severe erosive disease, making them candidates for early, aggressive therapy.
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