Article
T-cell receptor-major histocompatibility complex genetic interactions in rheumatoid arthritis.
Rheumatic diseases clinics of North America - 1 Nov 1992
Gregersen P K
Abstract excerpt
Rheumatoid arthritis (RA) is a complex multifactorial illness. It is proposed that multiple genes involved in immune recognition interact to produce a state of genetic susceptibility for RA. The role of HLA and T-cell receptor and other background genes is discussed, with an emphasis on their role in shaping the T-cell repertoire.
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