Article
T-cell receptor-major histocompatibility complex genetic interactions in rheumatoid arthritis.
Rheumatic diseases clinics of North America - 1 Nov 1992
Gregersen P K
Abstract excerpt
Rheumatoid arthritis (RA) is a complex multifactorial illness. It is proposed that multiple genes involved in immune recognition interact to produce a state of genetic susceptibility for RA. The role of HLA and T-cell receptor and other background genes is discussed, with an emphasis on their role in shaping the T-cell repertoire.
Topics
- Arthritis, Rheumatoid
- Epitopes
- Genetic Predisposition to Disease
- HLA Antigens
- Humans
- Major Histocompatibility Complex
- Models, Biological
- Polymorphism, Genetic
- Receptors, Antigen, T-Cell
- Selection, Genetic
- T-Lymphocytes