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Article

Loss of atheroprotective effect of estradiol in immunodeficient mice.

Endocrinology - 1 Jan 2000

Elhage R, Clamens S, Reardon-Alulis C, Getz G S, Fievet C, Maret A, Arnal J F, Bayard F

Abstract excerpt

Estradiol significantly decreases fatty streak formation in the aortic root of chow-fed apolipoprotein E-deficient mice. In contrast, immunodeficient mice with homozygous disruption at the recombinase activating gene 2 loci present fatty streak development that is insensitive to estradiol. Lymphocytes thus appear to be required for development of the atheroprotective effect of estradiol in this mouse model.

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Identifiers

PMID: 10614672
DOI: 10.1210/endo.141.1.7377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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