Article
Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro.
Hepatology (Baltimore, Md.) - 1 Dec 1998
Xiong X, Flores C, Yang H, Toole J J, Gibbs C S
Abstract excerpt
To determine whether adefovir is active against lamivudine-resistant hepatitis B virus (HBV), the inhibition constants of adefovir diphosphate and lamivudine triphosphate for wild-type and mutant human HBV DNA polymerases, which contain amino acid substitutions associated with lamivudine resistan...
Topics
- Adenine
- Amino Acid Sequence
- Anti-HIV Agents
- Baculoviridae
- DNA-Directed DNA Polymerase
- Drug Resistance
- Hepatitis B virus
- Humans
- Lamivudine
- Molecular Sequence Data
- Mutation
- Organophosphonates
- Recombinant Proteins