Article
A branched pathway governing the activation of a developmental transcription factor by regulated intramembrane proteolysis.
Molecular cell - 7 Jul 2006
Campo Nathalie, Rudner David Z
Abstract excerpt
The proteolytic activation of the membrane-associated transcription factor pro-sigma(K) is controlled by a signal transduction pathway during sporulation in the bacterium Bacillus subtilis. The pro-sigma(K) processing enzyme SpoIVFB, a membrane-embedded metalloprotease, is held inactive by two other integral-membrane proteins, SpoIVFA and BofA. We demonstrate that the signaling protease SpoIVB (IVB) triggers...
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