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Article

Intramembrane proteolytic cleavage of a membrane-tethered transcription factor by a metalloprotease depends on ATP.

Proceedings of the National Academy of Sciences of the United States of America - 22 Sept 2009

Zhou Ruanbao, Cusumano Christina, Sui Dexin, Garavito R Michael, Kroos Lee

Abstract excerpt

Regulated intramembrane proteolysis (RIP) involves cleavage of a transmembrane segment of a protein. RIP governs diverse processes in a wide variety of organisms and is carried out by different types of intramembrane proteases (IPs), including a large family of metalloproteases. The Bacillus subtilis SpoIVFB protein is a putative metalloprotease that cleaves membrane-tethered Pro-sigma(K), releasing sigma(K) to...

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Identifiers

PMID: 19805276
DOI: 10.1073/pnas.0901455106
PMCID: PMC2752518

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CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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