Article
A bacteriophage model system for studying topoisomerase inhibitors.
Advances in pharmacology (San Diego, Calif.) - 1 Jan 1994
Kreuzer K N
Abstract excerpt
The bacteriophage T4 provides a unique and informative system in which to study the mechanism of action of antitumor agents that inhibit type II DNA topoisomerases. The evolutionary conservation of inhibitor sensitivity provides a strong argument for a conserved inhibitor binding site at or very...
Topics
- Antineoplastic Agents
- Bacteriophage T4
- Binding Sites
- DNA Damage
- DNA Repair
- DNA, Viral
- Escherichia coli
- Mutation
- Topoisomerase II Inhibitors