Bacteriophage T4, a model system for understanding the mechanism of type II topoisomerase inhibitors.

doi:10.1016/s0167-4781(98)00145-6

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Article

Bacteriophage T4, a model system for understanding the mechanism of type II topoisomerase inhibitors.

Biochimica et biophysica acta - 1 Oct 1998

Kreuzer K N

Abstract excerpt

Bacteriophage T4 provides a simple model system for analyzing the mechanism of action of antitumor agents that inhibit DNA topoisomerases. The phage-encoded type II topoisomerase is sensitive to many of the same antitumor agents that inhibit mammalian type II topoisomerase, including m-AMSA, elli...

Topics

Amsacrine
Antineoplastic Agents
Bacteriophage T4
Binding Sites
DNA Damage
DNA Repair
DNA Topoisomerases, Type II
Drug Resistance
Enzyme Inhibitors
Mutation
Quinolines
Topoisomerase II Inhibitors

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