Article
HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies.
Nature medicine - 1 May 1997
Connors M, Kovacs J A, Krevat S, Gea-Banacloche J C, Sneller M C, Flanigan M, Metcalf J A, Walker R E, Falloon J, Baseler M, Feuerstein I, Masur H, Lane H C
Abstract excerpt
Changes in CD4+ T-cell surface marker phenotype and antigen receptor (TCR) repertoire were examined during the course of HIV infection and following therapy. A preferential decline in naive CD4+ T cells was noted as disease progressed. Following protease inhibitor therapy, naive CD4+ T cells incr...
Topics
- CD4-Positive T-Lymphocytes
- Disease Progression
- HIV Infections
- HIV Protease Inhibitors
- Humans
- Indinavir
- Interleukin-2
- Leukocyte Common Antigens
- Phenotype
- RNA, Messenger
- Receptors, Antigen, T-Cell, alpha-beta
- Twins, Monozygotic