Preimplantation access to maternal insulin and albumin increases fetal growth rate in mice

Abstract excerpt

Provision of the maternal factors, albumin and/or insulin to embryos in vitro restores preimplantation morphological development and cell proliferation to that seen in vivo. The hypothesis that the preimplantation effects of insulin or albumin would be reflected in increased fetal growth rate was examined. Two-cell embryos were cultured 48-50 h in medium supplemented with 0.17 micromol/l, 15 micromol/l albumin or...

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