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Prenatal Programming of Insulin Secretion in Intrauterine Growth Restriction

29 Jun 2013

Abstract excerpt

Intrauterine growth restriction (IUGR) impairs insulin secretion in humans and in animal models of IUGR. Several underlying mechanisms have been implicated, including decreased expression of molecular regulators of β-cell mass and function, in some cases shown to be due to epigenetic changes initiated by an adverse fetal environment. Alterations in cell cycle progression contribute to loss of β-cell mass, whereas...

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PMID: 23820120
DOI: 10.1097/grf.0b013e31829e5b29

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