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The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.

1990-05-01

Abstract excerpt

We have isolated the gene for a novel growth regulator, amphiregulin (AR), that is evolutionarily related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). AR is a bifunctional growth modulator: it interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. The 84-amino-acid mature pr...

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Literature Corpus work
624a2be3-47df-505b-bf0e-94cc59c9b67b
DOI
10.1128/mcb.10.5.1969
Open publication

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The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.DOI 10.1128/mcb.10.5.1969
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