Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

1 May 1990

Abstract excerpt

We have isolated the gene for a novel growth regulator, amphiregulin (AR), that is evolutionarily related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). AR is a bifunctional growth modulator: it interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. The 84-amino-acid mature...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glycosylation and Glycoproteins Research
Share to Growth Hormone and Insulin-like Growth Factors
Share to HER2/EGFR in Cancer Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 2325643
DOI: 10.1128/mcb.10.5.1969-1981.1990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory ActivityPMID 2325643Read ↗

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.Semantic proximity Read ↗

A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin.Semantic proximity Read ↗

Amphoterin as an extracellular regulator of cell motility: from discovery to diseaseSemantic proximity Read ↗

Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype.Semantic proximity Read ↗

Amphiregulin deletion strongly attenuates the development of estrogen receptor-positive tumors in p53 mutant mice.Semantic proximity Read ↗

Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line.Semantic proximity Read ↗

Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development.Semantic proximity Read ↗

Metalloproteinase-Mediated, Context-Dependent Function of Amphiregulin and HB-EGF in Human Keratinocytes and SkinSemantic proximity Read ↗

A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling.Semantic proximity Read ↗

The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.Semantic proximity Read ↗

Differential Regulation of Breast Cancer-Associated Genes by Progesterone Receptor Isoforms PRA and PRB in a New Bi-Inducible Breast Cancer Cell LineSemantic proximity Read ↗

THE RECEPTOR FOR EGF AND ITS LIGANDS - EXPRESSION, PROGNOSTIC VALUE AND TARGET FOR THERAPY IN CANCER (REVIEW)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.