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Article

Interdomain signaling in glutamine phosphoribosylpyrophosphate amidotransferase.

The Journal of biological chemistry - 17 Dec 1999

Bera A K, Chen S, Smith J L, Zalkin H

Abstract excerpt

The glutamine phosphoribosylpyrophosphate (PRPP) amidotransferase-catalyzed synthesis of phosphoribosylamine from PRPP and glutamine is the sum of two half-reactions at separated catalytic sites in different domains. Binding of PRPP to a C-terminal phosphoribosyltransferase domain is required to activate the reaction at the N-terminal glutaminase domain. Interdomain signaling was monitored by intrinsic tryptophan...

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PMID: 10593947
DOI: 10.1074/jbc.274.51.36498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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