Article
Crystal structures capture three states in the catalytic cycle of a pyridoxal phosphate (PLP) synthase.
The Journal of biological chemistry - 27 Feb 2015
Smith Amber Marie, Brown William Clay, Harms Etti, Smith Janet L
Abstract excerpt
PLP synthase (PLPS) is a remarkable single-enzyme biosynthetic pathway that produces pyridoxal 5'-phosphate (PLP) from glutamine, ribose 5-phosphate, and glyceraldehyde 3-phosphate. The intact enzyme includes 12 synthase and 12 glutaminase subunits. PLP synthesis occurs in the synthase active site by a complicated mechanism involving at least two covalent intermediates at a catalytic lysine. The first...
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