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Article

Inhibition of calpain blocks platelet secretion, aggregation, and spreading.

The Journal of biological chemistry - 17 Dec 1999

Croce K, Flaumenhaft R, Rivers M, Furie B, Furie B C, Herman I M, Potter D A

Abstract excerpt

Previous studies have indicated that the Ca(2+)-dependent protease, calpain, is activated in platelets within 30-60 s of thrombin stimulation, but specific roles of calpain in platelets remain to be identified. To directly test the functions of calpain during platelet activation, a novel strategy was developed for introducing calpain's specific biological inhibitor, calpastatin, into platelets prior to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10593923
DOI: 10.1074/jbc.274.51.36321
PMCID: PMC2727653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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