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Article

The role of calpain in the regulation of ADAM17-dependent GPIbalpha ectodomain shedding.

Archives of biochemistry and biophysics - 15 Mar 2010

Wang Zhicheng, Shi Quanwei, Yan Rong, Liu Guanglei, Zhang Weilin, Dai Kesheng

Abstract excerpt

There are evidence that both a disintegrin and metalloproteinase 17 (ADAM17) and calpain are involved in platelet glycoprotein (GP)Ibalpha ectodomain cleavage. However, the relationship between the two enzymes in the shedding process remains unclear. Here we show that calcium ionophore A23187- an...

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Source

Identifiers

PMID: 20060803
DOI: 10.1016/j.abb.2010.01.003

Genes

ADAM17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20060803-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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