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Article

Studies of the molecular mechanisms in the regulation of telomerase activity

1 Dec 1999

Abstract excerpt

Telomerase, a specialized RNA-directed DNA polymerase that extends telomeres of eukaryotic chromosomes, is repressed in normal human somatic cells but is activated during development and upon neoplasia. Whereas activation is involved in immortalization of neoplastic cells, repression of telomerase permits consecutive shortening of telomeres in a chromosome replication-dependent fashion. This cell cycle-dependent,...

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Share to Cancer Research and Treatments
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10593857
DOI: 10.1096/fasebj.13.15.2091

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