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Article

Stabilization and reactivation of the p53 tumor suppressor protein in nontumorigenic revertants of HeLa cervical cancer cells.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Nov 1999

Athanassiou M, Hu Y, Jing L, Houle B, Zarbl H, Mikheev A M

Abstract excerpt

We demonstrated previously that loss of in vitro transformation and in vivo tumorigenicity in two independent revertant clones of HeLa cells (designated HA and HF) resulted from dominant-acting genetic changes. Analysis of the p53 tumor suppressor gene revealed stabilization and at least partial restoration of wild-type p53 transactivation properties pathways in both revertants of HPV-induced cell transformation....

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PMID: 10593649

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Stabilization and reactivation of the p53 tumor suppressor protein in nontumorigenic revertants of HeLa cervical cancer cells.PMID 10593649Read ↗

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