Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53.

Abstract excerpt

Somatic mutations in the p53 tumor suppressor gene represent the single most common genetic alteration observed in human cancers. Interestingly, the great majority of malignant tumors of the cervix uteri contain wild-type p53 alleles together with the DNA of specific types of human papillomavirus...

Topics

• Base Sequence
• Carcinoma
• Female
• Genes, Tumor Suppressor
• Genetic Variation
• HeLa Cells
• Humans
• Molecular Sequence Data
• Neoplasm Proteins
• Nuclear Proteins
• Oncogene Proteins, Viral
• Papillomaviridae
• Plasmids
• Proto-Oncogene Proteins
• Proto-Oncogene Proteins c-mdm2
• Recombinant Proteins
• Repressor Proteins
• Suppression, Genetic