Article
Transient stabilization of p53 in non-small cell lung carcinoma cultures arrested for growth by retinoic acid.
Experimental cell research - 1 Sept 1994
Maxwell S A, Mukhopadhyay T
Abstract excerpt
Proliferation of five non-small cell lung carcinoma (NSCLC) cultures was inhibited after 16 h exposure to retinoic acid. We investigated whether expression of the p53 protein correlated with the growth pattern of NSCLC lines observed in the presence of retinoic acid Levels of wild-type p53 protei...
Topics
- Antibodies, Monoclonal
- Antibodies, Neoplasm
- Carcinoma, Non-Small-Cell Lung
- Cell Division
- Dose-Response Relationship, Drug
- Half-Life
- Humans
- Lung Neoplasms
- Mutation
- Protein Conformation
- Protein Processing, Post-Translational
- Tretinoin
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53