Article
Analysis of strains of Saccharomyces cerevisiae with amino acid substitutions in the Cu(A)-binding region of subunit II of cytochrome c oxidase.
Current genetics - 1 Nov 1999
Mazourek M, Torello A T, Cameron V
Abstract excerpt
Cytochrome c oxidase accepts electrons from cytochrome c and transfers them to oxygen to form water. Electrons enter the complex through the Cu(A) site, formed by two copper atoms bound to mitochondrially encoded subunit II. The effect of amino-acid alterations in one of the Cu(A) ligands and in an amino acid adjacent to another of the ligands in the yeast enzyme is examined. Substitution of tyrosine for the...
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