Article
Metal binding to Saccharomyces cerevisiae ferrochelatase.
Biochemistry - 19 Nov 2002
Karlberg Tobias, Lecerof David, Gora Monika, Silvegren Germund, Labbe-Bois Rosine, Hansson Mats, Al-Karadaghi Salam
Abstract excerpt
Ferrochelatase is the terminal enzyme in the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into protoporphyrin IX to produce protoheme IX. The crystal structures of ferrochelatase from Saccharomyces cerevisiae in free form, in complex with Co(II), a substrate metal ion, and in complex with two inhibitors, Cd(II) and Hg(I), are presented in this work. The enzyme is a homodimer, with clear...
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