The topology of CuA in relation to the other metal centres in cytochrome-c oxidase of Saccharomyces cerevisiae as determined by analysis of second-site reversions.

doi:10.1016/0167-4838(95)92373-4

Back to search

Article

The topology of CuA in relation to the other metal centres in cytochrome-c oxidase of Saccharomyces cerevisiae as determined by analysis of second-site reversions.

Biochimica et biophysica acta - 15 Nov 1995

Meunier B, Colson A M, Rich P R

Abstract excerpt

Second-site revertants were selected from a respiratory-deficient mutant carrying the mutation D369N located in a loop between helices IX and X close to H376 and H378, the proposed ligands of haem a3 and haem a, respectively. A reversion was observed in subunit II, in the vicinity of the CuA liga...

Topics

Binding Sites
Copper
Electron Transport Complex IV
Ligands
Mitochondria
Mutation
Protein Conformation
Protein Structure, Secondary
Saccharomyces cerevisiae
Suppression, Genetic

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.