Article
Cytochrome b-deficient mutants of the ubiquinol-cytochrome c oxidoreductase in Saccharomyces cerevisiae. Consequence for the functional and structural characteristics of the complex.
The Journal of biological chemistry - 25 Jul 1993
Lemesle-Meunier D, Brivet-Chevillotte P, di Rago J P, Slonimski P P, Bruel C, Tron T, Forget N
Abstract excerpt
We characterized six novel missense mutations in mitochondrial cytochrome b (C133Y, W142R, S206L, M221K, L282F, and G340E) which impair the respiratory growth of yeast and which have differential effects on the functioning and assembly of the bc1 complex. The mutations have been mapped geneticall...
Topics
- Amino Acid Sequence
- Cytochrome b Group
- DNA Mutational Analysis
- Electron Transport Complex III
- Molecular Sequence Data
- Mutation
- Oxygen Consumption
- Protein Folding
- Saccharomyces cerevisiae
- Spectrum Analysis