Article
Cytochrome b-deficient mutants of the ubiquinol-cytochrome c oxidoreductase in Saccharomyces cerevisiae. Consequence for the functional and structural characteristics of the complex.
The Journal of biological chemistry - 25 Jul 1993
Lemesle-Meunier D, Brivet-Chevillotte P, di Rago J P, Slonimski P P, Bruel C, Tron T, Forget N
Abstract excerpt
We characterized six novel missense mutations in mitochondrial cytochrome b (C133Y, W142R, S206L, M221K, L282F, and G340E) which impair the respiratory growth of yeast and which have differential effects on the functioning and assembly of the bc1 complex. The mutations have been mapped genetically in exons of the mitochondrial gene coding for apocytochrome b and their nucleotide sequence established. The mutants...
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