Article
Structural and functional analysis of deficient mutants in subunit I of cytochrome c oxidase from Saccharomyces cerevisiae.
Biochimica et biophysica acta - 31 Jul 1997
Ortwein C, Link T A, Meunier B, Colson-Corbisier A M, Rich P R, Brandt U
Abstract excerpt
Four point mutations in subunit I of cytochrome c oxidase from Saccharomyces cerevisiae that had been selected for respiratory incompetence but still contained spectrally detectable haem aa3 were analysed. The isolated mutant enzymes exhibited minor band shifts in their optical spectra and contained all eleven subunits. However, steady state activities were only a few percent compared to wild type enzyme. Using a...
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