Article
Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon.
Gastroenterology - 1 Jul 2000
Kim Y I, Shirwadkar S, Choi S W, Puchyr M, Wang Y, Mason J B
Abstract excerpt
BACKGROUND & AIMS: Diminished folate status has been observed to increase colorectal cancer risk. Folate plays an important role in DNA synthesis and repair. This study investigated the effects of dietary folate on DNA strand breaks in the p53 and Apc genes, and how these changes are related to steady-state levels of the corresponding transcripts. METHODS: Three groups of rats were fed diets containing 0, 2...
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