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Article

Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors.

Nature - 1 Mar 1990

Seto E, Mitchell P J, Yen T S

Abstract excerpt

The hepatitis B virus (HBV) X gene product (pX) could be important in disease pathogenesis because it is known to transactivate transcription from many viral and cellular gene promoters, including the HBV core gene promoter, the human immunodeficiency virus (HIV-1) long terminal repeat, and the c...

Topics

Animals
Base Sequence
Cell Line
Chloramphenicol O-Acetyltransferase
DNA-Binding Proteins
Enhancer Elements, Genetic
Humans
Molecular Sequence Data
Mutation
Plasmids
Recombinant Fusion Proteins
Simian virus 40

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Trans-Activators

Transcription Factor AP-2

Transcription Factors

Transcriptional Activation

Viral Regulatory and Accessory Proteins

Source

Identifiers

PMID: 2154703
DOI: 10.1038/344072a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2154703-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors.PMID 2154703Read ↗

HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein InteractionsSemantic proximity Read ↗

The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review).Semantic proximity Read ↗

Hepatitis B Virus X Protein: Structure, Function and BiologySemantic proximity Read ↗

pX, the HBV‐encoded coactivator, interacts with components of the transcription machinery and stimulates transcription in a TAF‐independent manner.Semantic proximity Read ↗

Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein.Semantic proximity Read ↗

Hepatitis B virus X protein inhibits nucleotide excision repairSemantic proximity Read ↗

Hepatitis B virus transcriptional activators: mechanisms and possible role in oncogenesisSemantic proximity Read ↗

Hepatitis B virus X protein interferes with cellular DNA repair.Semantic proximity Read ↗

Mutual functional antagonism of the simian virus 40 T antigen and the hepatitis B virus trans activator.Semantic proximity Read ↗

Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathwaySemantic proximity Read ↗

Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression.Semantic proximity Read ↗

pX, the HBV-encoded coactivator, suppresses the phenotypes of TBP and TAFII250 mutants.Semantic proximity Read ↗

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