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Article

Oligonucleotide-based inhibition of embryonic gene expression.

Nature biotechnology - 1 Dec 1999

Driver S E, Robinson G S, Flanagan J, Shen W, Smith L E, Thomas D W, Roberts P C

Abstract excerpt

We describe a technique to define gene function using antisense oligonucleotide (AS-ODN) inhibition of gene expression in mice. A single intravenous injection of an AS-ODN targeting vascular endothelial growth factor (VEGF) into pregnant mice between E7.5-8.5 resulted in a lack of primary angiogenesis. This enabled us to define the critical window required to inhibit VEGF expression and recapitulate the primary...

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Source

Identifiers

PMID: 10585715
DOI: 10.1038/70724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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