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Article

Antisense oligonucleotides delivered to the amniotic cavityin uteromodulate gene expression in the postnatal mouse

28 Sept 2016

Abstract excerpt

Congenital diseases account for a large portion of pediatric illness. Prenatal screening and diagnosis permit early detection of many genetic diseases. Fetal therapeutic strategies to manage disease processes in utero represent a powerful new approach for clinical care. A safe and effective fetal pharmacotherapy designed to modulate gene expression ideally would avoid direct mechanical engagement of the fetus and...

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PMID: 27683224
DOI: 10.1093/nar/gkw867

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