Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased Expression of Rat Synuclein in the Substantia Nigra Pars Compacta Identified by mRNA Differential Display in a Model of Developmental Target Injury

1 Dec 1999

Abstract excerpt

Human alpha-synuclein was identified on the basis of proteolytic fragments derived from senile plaques of Alzheimer's disease, and it is the locus of mutations in some familial forms of Parkinson's disease. Its normal function and whether it may play a direct role in neural degeneration remain unknown. To explore cellular responses to neural degeneration in the dopamine neurons of the substantia nigra, we have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Nerve injury and regeneration
Share to Nuclear Receptors and Signaling
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10582622
DOI: 10.1046/j.1471-4159.1999.0732586.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased Expression of Rat Synuclein in the Substantia Nigra Pars Compacta Identified by mRNA Differential Display in a Model of Developmental Target InjuryPMID 10582622Read ↗

Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD.Semantic proximity Read ↗

Synuclein‐1 is selectively up‐regulated in response to nerve growth factor treatment in PC12 cellsSemantic proximity Read ↗

Transcriptomic Profiling of Early Synucleinopathy in Rats Induced with Preformed FibrilsSemantic proximity Read ↗

Differential Expression and Distribution of α-, β-, and γ-Synuclein in the Developing Human Substantia NigraSemantic proximity Read ↗

Long-term RNAi knockdown of α-synuclein in the adult rat substantia nigra without neurodegenerationSemantic proximity Read ↗

In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal DegenerationSemantic proximity Read ↗

Elevated α-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's diseaseSemantic proximity Read ↗

Genetic inactivation of alpha-synuclein affects embryonic development of dopaminergic neurons of the substantia nigra, but not the ventral tegmental area, in mouse brainSemantic proximity Read ↗

?-Synuclein expression in substantia nigra and cortex in Parkinson's diseaseSemantic proximity Read ↗

Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson’s diseaseSemantic proximity Read ↗

The cDNA cloning and ontogeny of mouse alpha-synuclein.Semantic proximity Read ↗

Age-related gene expression changes in substantia nigra dopamine neurons of the rat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.