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Article

The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.

Development (Cambridge, England) - 1 Nov 1997

Kishimoto Y, Lee K H, Zon L, Hammerschmidt M, Schulte-Merker S

Abstract excerpt

Early dorsoventral pattern formation in vertebrate embryos is regulated by opposing activities of ventralizing bone morphogenetic proteins (BMPs) and dorsal-specific BMP antagonists such as Chordin, Noggin and Follistatin. Specific defects in early dorsoventral patterning have been recently found in a number of zebrafish mutants, which exhibit either a ventralized or dorsalized phenotype. One of these, the...

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Identifiers

PMID: 9409664
DOI: 10.1242/dev.124.22.4457

Genes

BMP2
BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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The molecular nature of zebrafish swirl: BMP2 function is essential during early dorsoventral patterning.PMID 9409664Read ↗

Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes.Semantic proximity Read ↗

Genetic analysis of dorsoventral pattern formation in the zebrafish: requirement of a BMP-like ventralizing activity and its dorsal repressor.Semantic proximity Read ↗

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WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation.Semantic proximity Read ↗

Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation.Semantic proximity Read ↗

Bmp activity establishes a gradient of positional information throughout the entire neural plate.Semantic proximity Read ↗

The ventralized ogon mutant phenotype is caused by a mutation in the zebrafish homologue of Sizzled, a secreted Frizzled-related protein.Semantic proximity Read ↗

Patterning the zebrafish axial skeleton requires early chordin function.Semantic proximity Read ↗

The ventralizing activity of Radar, a maternally expressed bone morphogenetic protein, reveals complex bone morphogenetic protein interactions controlling dorso-ventral patterning in zebrafish.Semantic proximity Read ↗

The role of chordin/Bmp signals in mammalian pharyngeal development and DiGeorge syndrome.Semantic proximity Read ↗

Smad1 and Smad5 have distinct roles during dorsoventral patterning of the zebrafish embryo.Semantic proximity Read ↗

The roles of BMPs, BMP antagonists, and the BMP signaling transducers Smad1 and Smad5 during dorsoventral patterning of the zebrafish embryo.Semantic proximity Read ↗

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