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Article

A constrained-likelihood approach to marker-trait association studies.

American journal of human genetics - 1 Nov 2005

Wang Kai, Sheffield Val C

Abstract excerpt

Marker-trait association analysis is an important statistical tool for detecting DNA variants responsible for genetic traits. In such analyses, an analysis model of the mean genetic effects of the genotypes is often specified. For instance, the effect of the disease allele on the trait is often specified to be dominant, recessive, additive, or multiplicative. Although this model-based approach is powerful when...

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PMID: 16252237
DOI: 10.1086/497434
PMCID: PMC1271386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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