Article
Genotype of glutathione S-transferase and other genetic configurations in myelodysplasia.
Leukemia research - 1 Nov 1999
Sasai Y, Horiike S, Misawa S, Kaneko H, Kobayashi M, Fujii H, Kashima K, Taniwaki M
Abstract excerpt
We examined polymorphisms of glutathione S-transferase (GST) genes in 159 Japanese patients with myelodysplasia and compared the incidence with that in 43 normal individuals to clarify their pathogenetic significance in myelodysplasia. In individuals with the GSTT1 null genotype, the odds ratios for disease risk were elevated to 2.65 (95%CI; 1.27-5.52) in de novo MDS, 4.62 (1.48-14.4) in therapy-related AML, and...
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