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Article

Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes.

Leukemia research - 1 Aug 2009

Fabiani Emiliano, D'Alò Francesco, Scardocci Alessandra, Greco Mariangela, Di Ruscio Annalisa, Criscuolo Marianna, Fianchi Luana, Pagano Livio, Hohaus Stefan, Leone Giuseppe, Voso Maria Teresa

Abstract excerpt

The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other...

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Source

Identifiers

PMID: 19027952
DOI: 10.1016/j.leukres.2008.10.012

Genes

GSTP1
GSTA1
GSTM1
GSTT1
NQO1
RAD51
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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