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Article

Benzo[a]pyrene Activates the Human p53 Gene through Induction of Nuclear Factor κB Activity

1 Dec 1999

Abstract excerpt

p53 is known to be recruited in response to DNA-damaging genotoxic stress and plays an important role in maintaining the integrity of the genome. In the present study, the effect of a potent lung cancer carcinogen, benzo[a]pyrene (B[a]P) on p53 expression was investigated. We showed that exposure of A549 and NIH 3T3 cells to B[a]P resulted in an increase in p53 mRNA levels and in p53 promoter activation,...

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PMID: 10575010
DOI: 10.1074/jbc.274.49.35240

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