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Article

Activation of p53 as a causal step for atherosclerosis induced by polycyclic aromatic hydrocarbons.

FEBS letters - 6 Feb 2006

Iwano Shunsuke, Shibahara Norihito, Saito Tetsuya, Kamataki Tetsuya

Abstract excerpt

This study was performed to prove our hypothesis that the metabolite(s) of polycyclic aromatic hydrocarbons (PAHs) caused the activation or phosphorylation of p53 via DNA damage to suppress the liver X receptor (LXR)-mediated signal transductions as a probably more direct mechanism. We found that LXR-mediated trans-activation was inhibited by 3-methylchoranthrene (MC) and doxorubicin (Dox) in HepG2 cells carrying...

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Identifiers

PMID: 16427050
DOI: 10.1016/j.febslet.2006.01.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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