Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) mice.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 1999

Casley W L, Menzies J A, Whitehouse L W, Moon T W

Abstract excerpt

Caffeine metabolite ratios have been widely used to measure cytochrome P-450 1A2 activity in humans. Serum paraxanthine/caffeine ratio is one such index of this activity. We had previously demonstrated genetic variation of this trait among inbred mouse strains. In the present study, we have undertaken a genome-wide scan for quantitative trait loci affecting this trait with an interval mapping approach on an F(2)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breeding
Share to Caffeine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP1A2

Share to Mice, Inbred C3H

Share to Multifactorial Inheritance

Share to Quantitative Trait, Heritable

Share to Sex Factors

Share to Theophylline

Source

Identifiers

PMID: 10570017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of quantitative trait loci affecting caffeine metabolism by interval mapping in a genome-wide scan of C3H/HeJ x APN F(2) mice.PMID 10570017Read ↗

Differences in caffeine 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains.Semantic proximity Read ↗

Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans.Semantic proximity Read ↗

A mouse-based strategy for cyclophosphamide pharmacogenomic discovery.Semantic proximity Read ↗

Genome-wide association study of caffeine metabolites provides new insights to caffeine metabolism and dietary caffeine-consumption behavior.Semantic proximity Read ↗

Using the Phenogen website for 'in silico' analysis of morphine-induced analgesia: identifying candidate genes.Semantic proximity Read ↗

Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate.Semantic proximity Read ↗

Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation.Semantic proximity Read ↗

Scanning of five chromosomes for alcohol consumption loci.Semantic proximity Read ↗

Quantitative Prediction of Human Pregnane X Receptor and Cytochrome P450 3A4 Mediated Drug-Drug Interaction in a Novel Multiple Humanized Mouse LineSemantic proximity Read ↗

Paraxanthine/Caffeine Concentration Ratios in Hair: An Alternative for Plasma-Based Phenotyping of Cytochrome P450 1A2?Semantic proximity Read ↗

Mapping of Quantitative Trait Loci Underlying Ethanol Metabolism in BXD Recombinant Inbred Mouse StrainsSemantic proximity Read ↗

Allele dose analysis in recombinant inbred strains: a tool for multiple phenotype analysis with implications for quantitative trait loci mapping.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.