Article
Genome scan for teratogen-induced clefting susceptibility loci in the mouse: evidence of both allelic and locus heterogeneity distinguishing cleft lip and cleft palate.
Proceedings of the National Academy of Sciences of the United States of America - 13 May 1997
Diehl S R, Erickson R P
Abstract excerpt
Nonsyndromic clefting of the lip and palate in humans has a highly complex etiology, with both multiple genetic loci and exposure to teratogens influencing susceptibility. Previous studies using mouse models have examined only very small portions of the genome. Here we report the findings of a genome-wide search for susceptibility genes for teratogen-induced clefting in the AXB and BXA set of recombinant inbred...
Topics
- 6-Aminonicotinamide
- Abnormalities, Drug-Induced
- Alleles
- Animals
- Chromosome Mapping
- Cleft Lip
- Cleft Palate
- Crosses, Genetic
- Disease Susceptibility
- Humans
- Mice
- Mice, Inbred A
- Mice, Inbred C57BL
- Phenytoin