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Article

Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani.

The EMBO journal - 1 Jul 1999

Phillips C L, Ullman B, Brennan R G, Hill C P

Abstract excerpt

The enzyme adenine phosphoribosyltransferase (APRT) functions to salvage adenine by converting it to adenosine-5-monophosphate (AMP). APRT deficiency in humans is a well characterized inborn error of metabolism, and APRT may contribute to the indispensable nutritional role of purine salvage in protozoan parasites, all of which lack de novo purine biosynthesis. We determined crystal structures for APRT from...

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Source

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Identifiers

PMID: 10393170
DOI: 10.1093/emboj/18.13.3533
PMCID: PMC1171432

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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