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Article

Calpain-resistant fragment(s) of alpha-synuclein regulates the synuclein-cleaving activity of 20S proteasome.

Archives of biochemistry and biophysics - 1 Nov 2006

Kim Hyun Jin, Lee Daekyun, Lee Choong-Hwan, Chung Kwang Chul, Kim Jongsun, Paik Seung R

Abstract excerpt

Alpha-synuclein is a pathological component of Parkinson's disease by participating in Lewy body formation. Imbalance in protein turnover could result in the abnormal protein aggregation responsible for eventual neuronal cell death. This in vitro digestion study showed that both m-calpain and 20S...

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PMID: 17005155
DOI: 10.1016/j.abb.2006.08.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17005155-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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