Article
Expression of CD40 and its ligand, CD40L, in intestinal lesions of Crohn's disease.
The American journal of gastroenterology - 1 Nov 1999
Battaglia E, Biancone L, Resegotti A, Emanuelli G, Fronda G R, Camussi G
Abstract excerpt
OBJECTIVE: Selected mechanisms of the immune system participate in the development of inflammatory bowel disease. Recently, overexpression of the ligand for CD40 (CD40L), a lymphocyte costimulatory molecule, was shown to induce severe inflammatory bowel disease in transgenic mice. In the present study, we examined the expression of CD40 and CD40L on surgical specimens of ileum from 12 patients with Crohn's...
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