Article
CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1.
Circulation - 27 Mar 2007
Zirlik Andreas, Maier Christoph, Gerdes Norbert, MacFarlane Lindsey, Soosairajah Juliana, Bavendiek Udo, Ahrens Ingo, Ernst Sandra, Bassler Nicole, Missiou Anna, Patko Zsofia, Aikawa Masanori, Schönbeck Uwe, Bode Christoph, Libby Peter, Peter Karlheinz
Abstract excerpt
BACKGROUND: Strong evidence supports a role for CD40 ligand (CD40L) as marker and mediator of inflammatory diseases such as atherosclerosis. Despite extensive characterization of CD40, the classic receptor of CD40L, its role in immune defense against inflammatory diseases remains uncertain. The present study aimed to characterize the contribution of CD40 signaling to atherogenesis. METHODS AND RESULTS:...
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