Article
DNA trinucleotide repeat expansion in neuropsychiatric patients.
Medical science monitor : international medical journal of experimental and clinical research - 1 Sept 2003
Mohmood Sameena, Sherwani Asma, Khan Fauzia, Khan Rizwan H, Azfer Asim
Abstract excerpt
Dynamic mutations in human genes result from unstable trinucleotide repeats which are expanded within the genome. These expansions of trinucleotide repeats have been shown to be the etiological factors in various neuropsychiatric diseases and other genetic disorders. This hypothesis is supported by various independent studies showing large expansion of trimeric repeats, such as CAG/CTG/CCG/CGG/AAG, in patient DNA...
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