Article
Chromosome aberrations in bone marrow cells from Japanese patients with thorotrastosis.
Radiation research - 1 Dec 1999
Tanosaki S, Minamihisamatsu M, Ishihara T, Hachiya M, Kumatori T, Akashi M
Abstract excerpt
Exposure of bone marrow cells to alpha-particle radiation causes various types of chromosome abnormalities and hematological malignancies. We performed chromosome analysis of hematopoietic stem cells from the bone marrow of 52 Japanese patients with thorotrastosis and 21 age-matched controls. The frequency of cells with stable chromosome abnormalities was significantly higher in the patients with thorotrastosis....
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