Article
Cytogenetic analysis of radiation-induced leukemia in Trp53-deficient C3H/He mice.
Radiation research - 1 Jul 2002
Ban Nobuhiko, Yoshida Kazuko, Aizawa Shiro, Wada Sachiko, Kai Michiaki
Abstract excerpt
C3H/He mice develop acute myeloid leukemia (AML) after whole-body irradiation, but the strain becomes highly susceptible to stem cell leukemia (SCL) when a null mutation is introduced into the Trp53 gene. To examine the etiology of SCL and the influence of chromosomal instability on leukemogenesis, 12 SCLs and two AMLs arising from Trp53-deficient C3H/He mice were investigated cytogenetically. Each SCL...
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